Based on what is currently known about the neuropathology of parkinson’s disease and its association with oxidative stress disease mechanism, write an essay describing the generation of an in vitro model, and what experiments you would perform to investigate the effect of the pathogenic mechanism on neuronal dysfunction.
Experimental plan section (including description of the methods for generation of the model, which controls would be included and why, what methods/assays/technologies you would use to investigate the effect of the oxidative stress mechanism, what are the advantages and limitations of the proposed plan? how would you relate your findings to studies using post-mortem tissue)
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