Clinical Immunology FBMS602

Diagnostic Assay Case Study 2014-15

You are provided with a brief case history of a pat ient below. Although
her symptoms are associated with an auto-immune condition there are
many other possible causes. The tentative diagnosis is of a condition
that can occur in either primary or secondary forms , the latter being
associated with a number of other auto-immune condi tions.
Confirmation of the diagnosis and the identificatio n of any associated
conditions requires determination of the presence o r absence of a
number of disease markers.
You should research the condition and laboratory te sts that can be
performed to confirm the diagnosis. You must write a report which
includes a brief introduction to the condition, particularly the
immunological aspects, and provides details of the investigations that
you would perform to confirm the diagnosis. You should comment on
how the markers you propose to measure are associated with the
condition, discuss other conditions with which they may be associated
and provide a rationale for how these measurements will aid diagnosis.
A description of treatments for her condition is no t required.

Patient Details

A 55-year old woman consults her GP having been suffering from dry
eyes and a dry mouth for several months. She also reports having had
repeated episodes of swelling around her ears. She is referred to a
specialist with a preliminary diagnosis of Sjögren syndrome.

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