Diagnostic Clinical Genome and Exome Sequencing

In “Diagnostic Clinical Genome and Exome Sequencing”, Biesecker et al. are critical of the way doctors have been ordering CGES tests in the past and offer new factors for a doctor to consider before ordering the CGES test. They define the basics of CGES testing and suggest various measures that should be taken prior to placing an order for CGES.
Is the database, currently, comprehensive? What are it’s strengths for exon/genome sequencing? What are it’s weaknesses? In actuality, what can be done with the database in terms of locating a caustic variant?