Disease Development

– the way diseases are developed (eye disease), its correlation with genes, development and evolution? The term paper must be related to subjects discussed in class. Attached are topics/subjects discussed in class, 6 articles that must be referenced in the term paper and instructions . ( A paper (10-12 pages) will be written in the style of a think piece that reviews and analyzes current literature regarding a topic including the 5-6 articles.) identify the articles main purpose/objective, hypotheses results, conclusion, etc. make connection between the articles and also between the topics/material discussed in class. Topic: Disease development – the way diseases are developed (eye disease), its correlation with genes, development and evolution? Articles to be refrenced to: 1. The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene Justice, Elizabeth D., Sarah J. Barnum, and Thomas Kidd. “The WAGR Syndrome Gene PRRG4 Is a Functional Homologue of the commissurelessAxon Guidance Gene.” Ed. Claude Desplan. PLoS Genetics 13.8 (2017): e1006865. PMC. Web. 29 Sept. 2017. https://www-ncbi-nlm-nih-gov.ezproxy1.lib.asu.edu/pmc/articles/PMC5578492/ 2. PAX6 expression in the developing human eye Nishina, S. et al. “PAX6 Expression in the Developing Human Eye.” The British Journal of Ophthalmology 83.6 (1999): 723–727. Print. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1723067/ 3. Variants in TRIM44 Cause Aniridia by Impairing PAX6 Expression Zhang, X. (2015). Variants in TRIM44 Cause Aniridia by Impairing PAX6 Expression. Human Mutation., 36(12), 1164-1167 https://onlinelibrary.wiley.com.ezproxy1.lib.asu.edu/doi/10.1002/humu.22907/full 4. The Genetics of Congenital Aniridia – A Guide for the Ophthalmologist. https://www.sciencedirect.com.ezproxy1.lib.asu.edu/science/article/pii/S0039625717301303?via%3Dihub 5. Improving molecular diagnosis of aniridia and WAGR syndrome using customized targeted array-based CGH. Blanco-Kelly, Fiona et al. “Improving Molecular Diagnosis of Aniridia and WAGR Syndrome Using Customized Targeted Array-Based CGH.” Ed. Anthony W.I. Lo. PLoS ONE 12.2 (2017): e0172363. PMC. Web. 29 Sept. 2017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322952/ 6. Pax and Paired https://www.nature.com/nsmb/journal/v2/n4/pdf/nsb0495-273b.pdf?foxtrotcallback=true Topics discussed in class 1. EvoDevo 2. Central dogma 3. Regulation of gene expression 4. Central dogma during development 5. Induction and competence 6. Cell specification and morphogen gradients 7. Model organisms 8. Genetic toolkit 9. Adaptation coadaptation and exaptation 10. Developmental bias and constraint 11. Developmental plasticity and evolution 12. Cell adhesion and migration 13. Evolution and multicellulatiry 14. Cleavage 15. GASTRULATION 16. Evolution of gastrulation 17. Notochord formation and neurulation 18. CNS development 19. Neuron specificity an axon guidance 20. Eye development and evolution 21. Taste touch and smell 22. Ear development 23. Neural crest cells and jaw evolution