Finding candidate genes using QTL analysis
“Suppose that you wanted to find the genetic basis of why Dobermans are so mean relative to Beagles and identify a candidate gene(s). Explain in
detail how you would accomplish this task and the details of each step. In other words, trace ALL the steps that you would need to accomplish in
order to create the animals and build the tools that we used. Also, explain which brain region was involved but even more details about the region
and gene(s). You may assume that Dobermans and Beagles are fully inbred, that their genomes have been sequenced, and that you will live long enough
to accomplish this study.”
*This “tool that we used”
refers to
Entrez gene
allen brain atlas
web QTL
UCSC Genome Browser
Pubmed
A little background that may help:
https://mdcune.psych.ucla.edu/modules/bioinformatics
(scroll down to DOWNLOAD BIOINFORMATICS FILES and (6) VIEW LECTURE AND LAB MATERIALS Lecture 3 ppt. and lab2lab3 should give an idea of what the
professor wants)
(email me, please, and I can give the ppt walking through what he wants in the essay)
Things to touch for sure:
-How to make recombinant inbred strains
-quantify the phenotype
-removing the error variance (eg. sex, age, body weight, brain weight) and other individual differences.
-Describe and define QTL
-if you had to add information about dogs in the GENENETWORK (http://webqtl.org) (since there are no dogs), what would you have to do?
-likelihood ratio statistics
-etc. again, there’s a ppt walkthrough on what he wants included in there.
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