Diagnostic Clinical Genome and Exome Sequencing

In “Diagnostic Clinical Genome and Exome Sequencing”, Biesecker et al. are critical of the way doctors have been ordering CGES tests in the past and offer new factors for a doctor to consider before ordering the CGES test. They define the basics of CGES testing and suggest various measures that should be taken prior to placing an order for CGES.
How do the researchers limit the scope of their review? What do they decide to focus on and what have they acknowledged to be leaving out? Is this an effective strategy?